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1

Inhibition of farnesyl pyrophosphate (FPP) and/or geranylgeranyl pyrophosphate (GGPP) biosynthesis and its implication in the treatment of cancers

Waller, Daniel D., Park, Jaeok, Tsantrizos, Youla S.

Journal:

Critical Reviews in Biochemistry and Molecular Biology

Year:

2019

Language:

english

File:

PDF, 2.37 MB

english, 2019

2

Unraveling the Prenylation–Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors

Lacbay, Cyrus M., Waller, Daniel D., Park, Jaeok, Gómez Palou, Mònica, Vincent, Félix, Huang, Xian Fang, Ta, Viviane, Berghuis, Albert M., Sebag, Michael, Tsantrizos, Youla S.

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 2.06 MB

english, 2018

3

P-Chiral, N-Phosphoryl Sulfonamide Brønsted Acids with an Intramolecular Hydrogen Bond Interaction that Modulates Organocatalysis

Yuan, Minglei, Mbaezue, Ifenna Irvin, Zhou, Zhi, Topić, Filip, Tsantrizos, Youla S.

Journal:

Organic & Biomolecular Chemistry

Year:

2019

Language:

english

File:

PDF, 1.04 MB

english, 2019

4

Chirality-Driven Mode of Binding of α-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS)

Feng, Yuting, Park, Jaeok, Li, Shi-Guang, Boutin, Rebecca, Viereck, Peter, Schilling, Matthew, Berghuis, Albert M., Tsantrizos, Youla S.

Journal:

Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 1.74 MB

english, 2019

5

Macrocyclic Inhibitors of the NS3 Protease as Potential Therapeutic Agents of Hepatitis C Virus Infection

Youla S. Tsantrizos, Gordon Bolger, Pierre Bonneau, Dale R. Cameron, Nathalie Goudreau, George Kukolj, Steven R. LaPlante, Montse Llinàs-Brunet, Herbert Nar, Daniel Lamarre

Journal:

Angewandte Chemie

Year:

2003

Language:

english

File:

PDF, 238 KB

english, 2003

6

Binding Mode Determination of Benzimidazole Inhibitors of the Hepatitis C Virus RNA Polymerase by a Structure and Dynamics Strategy

Steven R. LaPlante, Araz Jakalian, Norman Aubry, Yves Bousquet, Jean-Marie Ferland, James Gillard, Sylvain Lefebvre, Martin Poirier, Youla S. Tsantrizos, George Kukolj, Pierre L. Beaulieu

Journal:

Angewandte Chemie

Year:

2004

Language:

english

File:

PDF, 264 KB

english, 2004

7

Macrocyclic Inhibitors of the NS3 Protease as Potential Therapeutic Agents of Hepatitis C Virus Infection

Youla S. Tsantrizos, Gordon Bolger, Pierre Bonneau, Dale R. Cameron, Nathalie Goudreau, George Kukolj, Steven R. LaPlante, Montse Llinàs-Brunet, Herbert Nar, Daniel Lamarre

Journal:

Angewandte Chemie International Edition

Year:

2003

Language:

english

File:

PDF, 237 KB

english, 2003

8

Binding Mode Determination of Benzimidazole Inhibitors of the Hepatitis C Virus RNA Polymerase by a Structure and Dynamics Strategy

Steven R. LaPlante, Araz Jakalian, Norman Aubry, Yves Bousquet, Jean-Marie Ferland, James Gillard, Sylvain Lefebvre, Martin Poirier, Youla S. Tsantrizos, George Kukolj, Pierre L. Beaulieu

Journal:

Angewandte Chemie International Edition

Year:

2004

Language:

english

File:

PDF, 266 KB

english, 2004

9

The design of a potent inhibitor of the hepatitis C virus NS3 protease: BILN 2061—From the NMR tube to the clinic

Youla S. Tsantrizos

Journal:

Year:

2004

Language:

english

File:

PDF, 858 KB

english, 2004

10

ChemInform Abstract: Backbone Modifications of Aromatic Peptide Nucleic Acid (APNA) Monomers and Their Hybridization Properties with DNA and RNA.

Lee D. Fader, Michael Boyd, Youla S. Tsantrizos

Journal:

Year:

2001

File:

PDF, 25 KB

2001

11

ChemInform Abstract: Hybridization Properties of Aromatic Peptide Nucleic Acids: A Novel Class of Oligonucleotide Analogues.

Lee D. Fader, Youla S. Tsantrizos

Journal:

Year:

2002

File:

PDF, 24 KB

2002

12

Potent Inhibitors of the Hepatitis C Virus NS3 Protease: Design and Synthesis of Macrocyclic Substrate-Based β-Strand Mimics.

Nathalie Goudreau, Christian Brochu, Dale R. Cameron, Jean-Simon Duceppe, Anne-Marie Faucher, Jean-Marie Ferland, Chantal Grand-Maitre, Martin Poirier, Bruno Simoneau, Youla S. Tsantrizos

Journal:

Year:

2004

File:

PDF, 9 KB

2004

13

Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase

Joris W. De Schutter, Serge Zaretsky, Sarah Welbourn, Arnim Pause, Youla S. Tsantrizos

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 687 KB

english, 2010

14

Indole 5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase with nanomolar potency in cell-based subgenomic replicons (part 2): Central amino acid linker and right-hand-side SAR studies

Pierre L. Beaulieu, Catherine Chabot, Jianmin Duan, Michel Garneau, James Gillard, Eric Jolicoeur, Martin Poirier, Marc-André Poupart, Timothy A. Stammers, George Kukolj, Youla S. Tsantrizos

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 881 KB

english, 2011

15

Olefin ring-closing metathesis as a powerful tool in drug discovery and development – potent macrocyclic inhibitors of the hepatitis C virus NS3 protease

Youla S. Tsantrizos, Jean-Marie Ferland, Andrew McClory, Martin Poirier, Vittorio Farina, Nathan K. Yee, Xiao-jun Wang, Nizar Haddad, Xudong Wei, Jinghua Xu, Li Zhang

Journal:

Journal of Organometallic Chemistry

Year:

2006

Language:

english

File:

PDF, 202 KB

english, 2006

16

Synthesis of novel analogs of aromatic peptide nucleic acids (APNAs) with modified conformational and electrostatic properties

Lee D Fader, Eddie L Myers, Youla S Tsantrizos

Journal:

Year:

2004

Language:

english

File:

PDF, 352 KB

english, 2004

17

Antifungal antibiotics from Pisolithus tinctorius

Youla S. Tsantrizos, Harry H. Kope, J.André Fortin, Kelvin K. Ogilvie

Journal:

Year:

1991

Language:

english

File:

PDF, 713 KB

english, 1991

18

Synthesis of a novel 1,4-bridged calix[8]arene “Host” cavity

Youla S. Tsantrizos, Warren Chew, Lawrence D. Colebrook, Françoise Sauriol

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 273 KB

english, 1997

19

Biosynthetic origin of the tetrahydropyranyl side chain of verucopeptin

Youla S. Tsantrizos, Jianhua Shen, Laird A. Trimble

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 238 KB

english, 1997

20

Design of potent bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase via targeted interactions with the active site ‘capping’ phenyls

Joris W. De Schutter, Joseph Shaw, Yih-Shyan Lin, Youla S. Tsantrizos

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 673 KB

english, 2012

21

Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme’s active site closure

Park, Jaeok, Lin, Yih-Shyan, De Schutter, Joris W, Tsantrizos, Youla S, Berghuis, Albert M

Journal:

BMC Structural Biology

Year:

2012

Language:

english

File:

PDF, 1.48 MB

english, 2012

22

Discovery of thienopyrimidine-based inhibitors of the human farnesyl pyrophosphate synthase—Parallel synthesis of analogs via a trimethylsilyl ylidene intermediate

Leung, Chun-Yuen, Langille, Adrienne M., Mancuso, John, Tsantrizos, Youla S.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 839 KB

english, 2013

23

Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors

Stammers, Timothy A., Coulombe, René, Rancourt, Jean, Thavonekham, Bounkham, Fazal, Gulrez, Goulet, Sylvie, Jakalian, Araz, Wernic, Dominic, Tsantrizos, Youla, Poupart, Marc-André, Bös, Michael, McKer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 469 KB

english, 2013

24

Importance of Ligand Bioactive Conformation in the Discovery of Potent Indole-Diamide Inhibitors of the Hepatitis C Virus NS5B

LaPlante, Steven R., Gillard, James R., Jakalian, Araz, Aubry, Norman, Coulombe, René, Brochu, Christian, Tsantrizos, Youla S., Poirier, Martin, Kukolj, George, Beaulieu, Pierre L.

Journal:

Journal of the American Chemical Society

Year:

2010

Language:

english

File:

PDF, 498 KB

english, 2010

25

Design and Synthesis of Active Site Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Apoptosis and Inhibition of ERK Phosphorylation in Multiple Myeloma Cells

Lin, Yih-Shyan, Park, Jaeok, De Schutter, Joris W., Huang, Xian Fang, Berghuis, Albert M., Sebag, Michael, Tsantrizos, Youla S.

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 2.42 MB

english, 2012

26

Thienopyrimidine Bisphosphonate (ThPBP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Optimization and Characterization of the Mode of Inhibition

Leung, Chun Yuen, Park, Jaeok, De Schutter, Joris W., Sebag, Michael, Berghuis, Albert M., Tsantrizos, Youla S.

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.01 MB

english, 2013

27

Synthesis of fullerenes via the thermal plasma dissociation of hydrocarbons

Alexakis, Theodora, Tsantrizos, Peter G., Tsantrizos, Youla S., Meunier, Jean-Luc

Journal:

Applied Physics Letters

Year:

1997

Language:

english

File:

PDF, 371 KB

english, 1997

28

Multistage Screening Reveals Chameleon Ligands of the Human Farnesyl Pyrophosphate Synthase: Implications to Drug Discovery for Neurodegenerative Diseases

De Schutter, Joris W., Park, Jaeok, Leung, Chun Yuen, Gormley, Patrick, Lin, Yih-Shyan, Hu, Zheping, Berghuis, Albert M., Poirier, Judes, Tsantrizos, Youla S.

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 4.80 MB

english, 2014

29

Stereoselective Synthesis of a Thymine Derivative of ( S )-2-Hydroxy-4-(2-aminophenyl)butanoic Acid. A Novel Building Block for the Synthesis of Aromatic Peptidic Nucleic Acid Oligomers 1

Tsantrizos, Youla S., Lunetta, Jacqueline F., Boyd, Michael, Fader, Lee D., Wilson, Marie-Claire

Journal:

Journal of Organic Chemistry

Year:

1997

Language:

english

File:

PDF, 268 KB

english, 1997

30

Structural Assignment of the Peptide Antibiotic LP237-F8, a Metabolite of Tolypocladium geodes

Tsantrizos, Youla S., Pischos, Sotiria, Sauriol, Françoise

Journal:

Journal of Organic Chemistry

Year:

1996

Language:

english

File:

PDF, 151 KB

english, 1996

31

Enzymatic Formation of Isochamigrene, a Novel Sesquiterpene, by Alteration of the Aspartate-Rich Region of Trichodiene Synthase J. Am. Chem. Soc. 1996 , 118 , 8499−8500

Cane, David E., Xue, Qun, Van Epp, James E., Tsantrizos, Youla S.

Journal:

Journal of the American Chemical Society

Year:

1997

Language:

english

File:

PDF, 66 KB

english, 1997

32

Backbone Modifications of Aromatic Peptide Nucleic Acid (APNA) Monomers and Their Hybridization Properties with DNA and RNA

Fader, Lee D., Boyd, Michael, Tsantrizos, Youla S.

Journal:

Journal of Organic Chemistry

Year:

2001

Language:

english

File:

PDF, 108 KB

english, 2001

33

Aristolochene Synthase. Elucidation of the Cryptic Germacrene A Synthase Activity Using the Anomalous Substrate Dihydrofarnesyl Diphosphate

Cane, David E., Tsantrizos, Youla S.

Journal:

Journal of the American Chemical Society

Year:

1996

Language:

english

File:

PDF, 142 KB

english, 1996

34

Enzymatic Formation of Isochamigrene, a Novel Sesquiterpene, by Alteration of the Aspartate-Rich Region of Trichodiene Synthase

Cane, David E., Xue, Qun, Van Epp, James E., Tsantrizos, Youla S.

Journal:

Journal of the American Chemical Society

Year:

1996

Language:

english

File:

PDF, 62 KB

english, 1996

35

Potent Inhibitors of the Hepatitis C Virus NS3 Protease: Design and Synthesis of Macrocyclic Substrate-Based β-Strand Mimics

Goudreau, Nathalie, Brochu, Christian, Cameron, Dale R., Duceppe, Jean-Simon, Faucher, Anne-Marie, Ferland, Jean-Marie, Grand-Maître, Chantal, Poirier, Martin, Simoneau, Bruno, Tsantrizos, Youla S.

Journal:

Journal of Organic Chemistry

Year:

2004

Language:

english

File:

PDF, 498 KB

english, 2004

36

Solid-Phase Synthesis of Peptidomimetic Inhibitors for the Hepatitis C Virus NS3 Protease

Poupart, Marc-André, Cameron, Dale R., Chabot, Catherine, Ghiro, Elise, Goudreau, Nathalie, Goulet, Sylvie, Poirier, Martin, Tsantrizos, Youla S.

Journal:

Journal of Organic Chemistry

Year:

2001

Language:

english

File:

PDF, 335 KB

english, 2001

37

Peptidomimetic Therapeutic Agents Targeting the Protease Enzyme of the Human Immunodeficiency Virus and Hepatitis C Virus

Tsantrizos, Youla S.

Journal:

Accounts of Chemical Research

Year:

2008

Language:

english

File:

PDF, 1.98 MB

english, 2008

38

Modular Assembly of Purine-like Bisphosphonates as Inhibitors of HIV-1 Reverse Transcriptase

Lacbay, Cyrus M., Mancuso, John, Lin, Yih-Shyan, Bennett, Nicholas, Götte, Matthias, Tsantrizos, Youla S.

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 757 KB

english, 2014

39

Studies on the Biosynthesis of the Fungal Metabolite Oudenone. 2. Synthesis and Enzymatic Cyclization of an α-Diketone, Open-Chain Precursor into Oudenone in Cultures of Oudemansiella r adicata

Tsantrizos, Youla S., Yang, Xianshu, McClory, Andrew

Journal:

Journal of Organic Chemistry

Year:

1999

Language:

english

File:

PDF, 176 KB

english, 1999

40

Biosynthesis of the Hypotensive Metabolite Oudenone by Oudemansiella radicata. 1. Intact Incorporation of a Tetraketide Chain Elongation Intermediate

Tsantrizos, Youla S., Zhou, Fei, Famili, Parsa, Yang, Xianshu

Journal:

Journal of Organic Chemistry

Year:

1995

Language:

english

File:

PDF, 991 KB

english, 1995

41

RCM of Tripeptide Dienes Containing a Chiral Vinylcyclopropane Moiety: Impact of Different Ru-Based Catalysts on the Stereochemical Integrity of the Macrocyclic Products

Poirier, Martin, Aubry, Norman, Boucher, Colette, Ferland, Jean-Marie, LaPlante, Steve, Tsantrizos, Youla S.

Journal:

Journal of Organic Chemistry

Year:

2005

Language:

english

File:

PDF, 206 KB

english, 2005

42

Hybridization Properties of Aromatic Peptide Nucleic Acids: A Novel Class of Oligonucleotide Analogues

Fader, Lee D., Tsantrizos, Youla S.

Journal:

Organic Letters

Year:

2002

Language:

english

File:

PDF, 50 KB

english, 2002

43

Phytotoxic metabolites of Phomopsis convolvulus , a host-specific pathogen of field bindweed

Tsantrizos, Youla S., Ogilvie, Kelvin K., Watson, Alan K.

Journal:

Canadian Journal of Chemistry

Year:

1992

Language:

english

File:

PDF, 641 KB

english, 1992

44

Approaches towards the synthesis of a sulfur analog of ergosterol peroxide

Tsantrizos, Youla S., Folkins, Patricia L., Britten, James F., Harpp, David N., Ogilvie, Kelvin K.

Journal:

Canadian Journal of Chemistry

Year:

1992

Language:

english

File:

PDF, 493 KB

english, 1992

45

Determination of the absolute stereochemistry of the fungal metabolite ( R )-(−)-2-(4′-hydroxyphenyl)-2-hydroxyethanoic acid (pisolithin B)

Tsantrizos, Youla S., Ogilvie, Kelvin K.

Journal:

Canadian Journal of Chemistry

Year:

1991

Language:

english

File:

PDF, 476 KB

english, 1991

46

Peptaibol metabolites of Tolypocladium geodes

Tsantrizos, Youla S., Pischos, Sotiria, Sauriol, Françoise, Widden, Paul

Journal:

Canadian Journal of Chemistry

Year:

1996

Language:

english

File:

PDF, 470 KB

english, 1996

47

Novel quinazolinones and enniatins from Fusarium lateritium Nees

Tsantrizos, Youla S., Xu, Xiao-Jin, Sauriol, Françoise, Hynes, Rosemary C.

Journal:

Canadian Journal of Chemistry

Year:

1994

Language:

english

File:

PDF, 26 KB

english, 1994

48

C -Nucleosides and related compounds. XV. The synthesis of D , L -2′- epi -showdomycin and D , L -showdomycin

Just, George, Liak, T. J., Lim, Mu-Ill, Potvin, Pierre, Tsantrizos, Youla S.

Journal:

Canadian Journal of Chemistry

Year:

1980

Language:

english

File:

PDF, 741 KB

english, 1980

49

Novel quinazolinones and enniatins from Fusarium lateritium Nees

Tsantrizos, Youla S., Xu, Xiao-Jin, Sauriol, Françoise, Hynes, Rosemary C.

Journal:

Canadian Journal of Chemistry

Year:

1993

Language:

english

File:

PDF, 429 KB

english, 1993

50

β-Lactams. IX. The synthesis of 7-β-phenylacetamido-3′-hydroxybenzo-[3,4]- O -2-isocephem, a weak antibacterial β-lactam antibiotic

Just, George, Tsantrizos, Youla S., Ugolini, Antonio

Journal:

Canadian Journal of Chemistry

Year:

1981

Language:

english

File:

PDF, 585 KB

english, 1981